SCHEMBL2665459

SCHEMBL2665459

CN(c1ccccc1)S(=O)(=O)c1cccc(NC(=O)N(Cc2ccc(C(=O)NCC(F)C(=O)O)cc2)c2ccc(C3CCCCC3)cc2)c1

nearest known ligand 0.62

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GCGR P47871 11/20 0.62
GIPR P48546 9/20 0.62
MAPT P10636 1/20 0.45
ALDH1A1 P00352 2/20 0.43
MAPK1 P28482 2/20 0.43
LMNA P02545 1/20 0.43
HTT P42858 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.42
ADRB2 P07550 1/20 0.42
OPRM1 P35372 1/20 0.42
OPRK1 P41145 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2665617 0.92 GCGR (0.73) GCGRGIPRMAPT
SCHEMBL2665463 0.92 GCGR (0.60) GCGRGIPRMAPTOPRM1OPRK1
SCHEMBL2665786 0.91 GCGR (0.66) GCGRGIPROPRM1OPRK1
SCHEMBL2665467 0.89 GCGR (0.58) GCGRGIPROPRM1OPRK1
SCHEMBL4092712 0.88 GCGR (0.69) GCGRGIPRMAPTALDH1A1MAPK1
SCHEMBL2665594 0.87 GCGR (0.69) GCGRGIPR
SCHEMBL9071764 0.86 GCGR (0.69) GCGRGIPR
SCHEMBL2665458 0.86 GCGR (0.63) GCGRGIPRALDH1A1MAPK1LMNA
SCHEMBL9071788 0.86 GCGR (0.68) GCGRGIPR
SCHEMBL9071790 0.85 GCGR (0.70) GCGRGIPR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002000612-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 2002-01-03 WO disclosed