Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 6/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CASP6 | P55212 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | CTH | P32929 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26656751 | 1.00 | CTSB (0.56) | CTSBTDP1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL26656750 | 1.00 | CTSB (0.56) | CTSBTDP1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL26656754 | 0.86 | TDP1 (0.55) | CTSBTDP1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL27552681 | 0.83 | TDP1 (0.52) | CTSBTDP1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL13825366 | 0.80 | CTSB (0.49) | CTSBTDP1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19667840 | 0.79 | GABRA1 (0.39) | TDP1ALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL7788656 | 0.79 | TDP1 (0.80) | CTSBTDP1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL26658643 | 0.79 | CTSB (0.51) | CTSBTDP1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL28691904 | 0.79 | CTSB (0.47) | CTSBTDP1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6256628 | 0.78 | ALDH1A1 (0.57) | TDP1ALDH1A1SMN1; SMN2MAPTKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339991-A1 | HYPOXIA-ACTIVATED DNA ALKYLATING AGENT AND MEDICAL USE THEREOF | ASCENTAWITS PHARMACEUTICALS, LTD. (CN) | 2023-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339991-A1 | HYPOXIA-ACTIVATED DNA ALKYLATING AGENT AND MEDICAL USE THEREOF | HIF1AN, HIF1A, MGMT | CTSB 4076/4885TDP1 254/4885ALDH1A1 1217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.