Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667485 | 0.87 | GCK (0.45) | GCKSMN1; SMN2MAPTHPGDCASP3 | |
| SCHEMBL2667487 | 0.85 | MAPK1 (0.41) | SMN1; SMN2CASP3SENP8SENP6RAB9A | |
| SCHEMBL2667598 | 0.82 | NPC1 (0.53) | GCKSMN1; SMN2BRD4MAPTHPGD | |
| SCHEMBL9070865 | 0.82 | SMN1; SMN2 (0.50) | GCKSMN1; SMN2BRD4MAPTHPGD | |
| SCHEMBL2667826 | 0.81 | MAPK1 (0.55) | SMN1; SMN2MAPTALDH1A1NPC1MEN1 | |
| SCHEMBL2667670 | 0.81 | GCK (0.54) | GCKSMN1; SMN2BRD4MAPTHPGD | |
| SCHEMBL2667602 | 0.81 | SMN1; SMN2 (0.59) | GCKSMN1; SMN2BRD4MAPTRAB9A | |
| SCHEMBL2667721 | 0.80 | GCK (0.56) | GCKSMN1; SMN2BRD4MAPTHPGD | |
| SCHEMBL2667488 | 0.80 | GCK (0.53) | GCK | |
| SCHEMBL2667594 | 0.79 | GCK (0.49) | GCKSMN1; SMN2BRD4MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |