Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | HTT | P42858 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | F2 | P00734 | 6/20 | 0.41 |
| ▸ | F12 | P00748 | 2/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29767948 | 1.00 | ALOX15 (0.44) | ALOX15HSD17B10MAPTHTTSMN1; SMN2 | |
| SCHEMBL29767956 | 0.89 | ALOX15 (0.46) | ALOX15HSD17B10MAPTHTTSMN1; SMN2 | |
| SCHEMBL26675362 | 0.89 | ALOX15 (0.46) | ALOX15HSD17B10MAPTHTTSMN1; SMN2 | |
| SCHEMBL30675610 | 0.89 | ALOX15 (0.46) | ALOX15HSD17B10MAPTHTTSMN1; SMN2 | |
| SCHEMBL26675344 | 0.88 | ALOX15 (0.47) | ALOX15HSD17B10MAPTHTTSMN1; SMN2 | |
| SCHEMBL26834610 | 0.88 | ALOX15 (0.47) | ALOX15HSD17B10MAPTHTTSMN1; SMN2 | |
| SCHEMBL29767952 | 0.88 | ALOX15 (0.47) | ALOX15HSD17B10MAPTHTTSMN1; SMN2 | |
| SCHEMBL26834617 | 0.87 | ENPP3 (0.38) | MAPTHTTSMN1; SMN2TP53PKM | |
| SCHEMBL26675432 | 0.84 | ALOX15 (0.48) | ALOX15HSD17B10MAPTHTTSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL26675303 | 0.84 | ALOX15 (0.45) | ALOX15HSD17B10MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230382911-A1 | PYRAZOLEAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230382911-A1 | PYRAZOLEAMIDE DERIVATIVES | P2RY1, P2RX1, P2RX5 | ALOX15 3863/4885HSD17B10 2897/4885MAPT 3058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.