Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2668579 | 0.87 | ATM (0.39) | ATMGCKALDH1A1MEN1KMT2A | |
| SCHEMBL2668583 | 0.79 | MCL1 (0.42) | ATMMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL1330053 | 0.77 | GCK (0.71) | GCK | |
| SCHEMBL9072456 | 0.76 | CXCR1 (0.45) | GCKRAB9AMAPTCXCR1CXCR2 | |
| SCHEMBL1328203 | 0.76 | GCK (0.67) | GCKALDH1A1 | |
| SCHEMBL1330033 | 0.75 | GCK (0.47) | GCK | |
| SCHEMBL16488514 | 0.74 | GCK (0.39) | GCK | |
| SCHEMBL1329481 | 0.74 | GCK (0.67) | GCK | |
| SCHEMBL14485982 | 0.74 | CXCR1 (0.40) | GCKALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL28897181 | 0.73 | CYP1A2 (0.59) | ATMALDH1A1RAB9ALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117381-A2 | 2 -AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2007-10-18 | — | — | WO | disclosed |