Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9072456 | 0.89 | CXCR1 (0.45) | GCKRAB9ATRPC6MAPT | |
| SCHEMBL2667557 | 0.87 | ATM (0.39) | ATMGCKALDH1A1MEN1KMT2A | |
| SCHEMBL2668583 | 0.82 | MCL1 (0.42) | ATMMEN1KMT2ARAB9ACYP1A2 | |
| SCHEMBL9072457 | 0.81 | CYP1A2 (0.40) | ATMALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL15196365 | 0.80 | MAPK1 (0.43) | FYN | |
| SCHEMBL16488510 | 0.78 | CXCR1 (0.38) | ALDH1A1KMT2AMAPT | |
| SCHEMBL1329022 | 0.77 | CXCR1 (0.40) | ALDH1A1MEN1KMT2ARAB9ACYP1A2 | |
| SCHEMBL1330053 | 0.77 | GCK (0.71) | GCK | |
| SCHEMBL16429390 | 0.76 | HSD17B10 (0.36) | ALDH1A1MEN1KMT2ARAB9ACYP1A2 | |
| SCHEMBL1328203 | 0.75 | GCK (0.67) | GCKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2543667-A1 | 2-aminopyridine analogs as glucokinase activators | Array Biopharma, Inc. (US) | 2013-01-09 | — | — | EP | disclosed |
| WO-2007117381-A9 | 2 -AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2007117381-A2 | 2 -AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2007-10-18 | — | — | WO | disclosed |