Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2668579 | 0.82 | ATM (0.39) | ATMCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2667557 | 0.79 | ATM (0.39) | ATMKDM4EHSD17B10LMNARAB9A | |
| SCHEMBL28897181 | 0.75 | CYP1A2 (0.59) | ATMMAPK1L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL3106153 | 0.74 | PKM (0.42) | MAPK1L3MBTL1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL23226196 | 0.73 | MTNR1A (0.66) | ATMTHRBL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL22614919 | 0.72 | HTT (0.48) | ATMMAPK1L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL19990144 | 0.72 | CYP1A2 (0.47) | CYP1A2CYP3A4CYP2C19NPC1GAA | |
| SCHEMBL9072456 | 0.71 | CXCR1 (0.45) | L3MBTL1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL10588609 | 0.71 | LMNA (0.47) | MAPK1KDM4EHSD17B10MTNR1AMTNR1B | |
| SCHEMBL23406153 | 0.71 | TDP1 (0.46) | LMNACASP3SENP8SENP7SENP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117381-A9 | 2 -AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2008-03-27 | — | — | WO | disclosed |