Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 3/20 | 0.52 |
| ▸ | SMARCA4 | P51532 | 3/20 | 0.52 |
| ▸ | PBRM1 | Q86U86 | 3/20 | 0.52 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30666247 | 1.00 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1PARP1SCD5 | |
| SCHEMBL30666241 | 0.81 | OXTR (0.39) | PARP1SCD5CYP11B2GPR119EGLN2 | |
| SCHEMBL26683395 | 0.81 | OXTR (0.39) | PARP1SCD5CYP11B2GPR119EGLN2 | |
| SCHEMBL27172162 | 0.80 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1GPR119NR1I2 | |
| SCHEMBL31293622 | 0.80 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1PARP1SCD5 | |
| SCHEMBL26683378 | 0.79 | SMARCA2 (0.50) | SMARCA2SMARCA4PBRM1PARP1SCD5 | |
| SCHEMBL30666283 | 0.79 | SMARCA2 (0.50) | SMARCA2SMARCA4PBRM1PARP1SCD5 | |
| SCHEMBL26683528 | 0.79 | PBRM1 (0.40) | SMARCA2SMARCA4PBRM1NR1I2 | |
| SCHEMBL30666248 | 0.78 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1SCD5CYP11B2 | |
| SCHEMBL26683210 | 0.78 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1SCD5CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250304596-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC (US) | 2025-10-02 | — | — | US | disclosed |
| WO-2023220137-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250304596-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | VHL, BRCA1, SF3B5 | SMARCA2 67/4885SMARCA4 22/4885PBRM1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.