Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | MARK3 | P27448 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | CLK2 | P49760 | 2/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.47 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31240484 | 0.87 | JAK2 (0.63) | JAK2DYRK1AJAK1ULK1 | |
| SCHEMBL26686431 | 0.87 | JAK2 (0.63) | JAK2DYRK1AJAK1ULK1 | |
| SCHEMBL26685865 | 0.86 | ULK1 (0.61) | JAK2ULK1F11 | |
| SCHEMBL31240358 | 0.86 | ULK1 (0.61) | JAK2ULK1F11 | |
| SCHEMBL26685861 | 0.86 | JAK2 (0.56) | JAK2DYRK1AJAK3JAK1PLK4 | |
| SCHEMBL30633352 | 0.86 | JAK2 (0.56) | JAK2DYRK1AJAK3JAK1PLK4 | |
| SCHEMBL26886635 | 0.85 | JAK2 (0.48) | JAK2DYRK1AJAK3PLK4DAPK3 | |
| SCHEMBL30633127 | 0.85 | JAK2 (0.48) | JAK2DYRK1AJAK3PLK4DAPK3 | |
| SCHEMBL31240493 | 0.84 | WNT3A (0.57) | JAK2DYRK1ACDK1CDK2CLK2 | |
| SCHEMBL31240315 | 0.83 | MAPK1 (0.56) | JAK2DYRK1AJAK3PLK4DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023218201-A1 | IKK INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2023-11-16 | — | — | WO | claimed |
| WO-2023218201-A1 | IKK INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2023-11-16 | — | — | WO | disclosed |