Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 6/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28422762 | 0.82 | SLC6A2 (0.39) | SLC6A4SLC6A3CHRM2KDM4EPOLB | |
| SCHEMBL5150562 | 0.78 | CHRM2 (0.50) | SLC6A4SLC6A3CHRM2MEN1KMT2A | |
| SCHEMBL13159608 | 0.77 | CHRM2 (0.69) | SLC6A4SLC6A3CHRM2MEN1KMT2A | |
| SCHEMBL26690453 | 0.74 | MEN1 (0.48) | CHRM2MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL8446073 | 0.72 | SCN8A (0.36) | CHRM2SCN8ACYP3A4HTR1B | |
| SCHEMBL17113747 | 0.72 | CYP3A4 (0.42) | MEN1KMT2AKDM4ECYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL8444362 | 0.71 | RAD52 (0.36) | CHRM2SCN8ACYP3A4HTR1B | |
| SCHEMBL11630639 | 0.71 | NOS2 (0.37) | SMN1; SMN2CYP1A2CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL13718474 | 0.71 | MAPT (0.42) | CHRM2MEN1KMT2AKDM4ECYP1A2 | |
| SCHEMBL23917256 | 0.70 | ALDH1A1 (0.43) | CHRM2KDM4EHRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |