Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 2/20 | 0.32 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26535842 | 0.80 | ROCK2 (0.35) | CACNA1GCACNA1IKDM4ECYP1A2CYP2D6 | |
| SCHEMBL1083122 | 0.78 | CACNA1G (0.45) | RAF1CACNA1GCACNA1IKDM4ECACNA1H | |
| SCHEMBL2669276 | 0.76 | GAA (0.40) | FFAR1KDM4EALOX15LMNAALDH1A1 | |
| SCHEMBL11918947 | 0.75 | — | — | |
| SCHEMBL23642505 | 0.74 | FFAR1 (0.34) | FFAR1 | |
| SCHEMBL223674 | 0.74 | ALDH1A1 (0.42) | IGF1RFFAR1TDP1ALOX5APALDH1A1 | |
| SCHEMBL22290623 | 0.74 | FFAR1 (0.34) | FFAR1SMN1; SMN2 | |
| SCHEMBL22445326 | 0.74 | FFAR1 (0.34) | FFAR1 | |
| SCHEMBL20464576 | 0.74 | AR (0.35) | FFAR1KDM4E | |
| SCHEMBL23985319 | 0.74 | KDM4E (0.39) | CACNA1GCACNA1IKDM4ECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009127546-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-22 | — | — | WO | disclosed |