Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | USP5 | P45974 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18950259 | 0.85 | CYP2C9 (0.57) | CYP2C9USP5ALDH1A1MEN1KMT2A | |
| SCHEMBL28847652 | 0.83 | ALDH1A1 (0.50) | CYP2C9ALDH1A1NOS3NOS1SMN1; SMN2 | |
| SCHEMBL6911963 | 0.81 | TSHR (0.57) | ALDH1A1KMT2ASMN1; SMN2RXRARXRB | |
| SCHEMBL17319344 | 0.81 | MAPT (0.48) | ALDH1A1NOS3NOS1KMT2ASMN1; SMN2 | |
| SCHEMBL1262317 | 0.81 | MAPT (0.48) | ALDH1A1NOS3NOS1KMT2ASMN1; SMN2 | |
| SCHEMBL891852 | 0.81 | TSHR (0.57) | ALDH1A1KMT2ASMN1; SMN2RXRARXRB | |
| SCHEMBL6912492 | 0.81 | TSHR (0.57) | ALDH1A1KMT2ASMN1; SMN2RXRARXRB | |
| SCHEMBL12600654 | 0.79 | PARP10 (0.53) | ALDH1A1NOS3NOS1KMT2AHTT | |
| SCHEMBL2422833 | 0.79 | PARP10 (0.53) | ALDH1A1NOS3NOS1KMT2AHTT | |
| SCHEMBL40655 | 0.79 | NOS3 (0.54) | ALDH1A1NOS3NOS1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008098244-A1 | NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR | METABASIS THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |