Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | HTR2B | P41595 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 4/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29757929 | 1.00 | MAPT (0.55) | MAPTHTR2BMEN1TP53CYP1A2 | |
| SCHEMBL28516762 | 0.82 | MAOB (0.74) | MAPTHTR2BMEN1TP53CYP1A2 | |
| SCHEMBL9544360 | 0.77 | MAPT (0.65) | MAPTHTR2BMEN1TP53CYP1A2 | |
| SCHEMBL12110170 | 0.76 | HTR2B (0.64) | MAPTHTR2BMEN1TP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL9400672 | 0.76 | HTR2C (0.65) | MAPTHTR2BMEN1TP53CYP1A2 | |
| SCHEMBL9400638 | 0.76 | HTR2B (0.67) | MAPTHTR2BMEN1TP53CYP1A2 | |
| SCHEMBL26697246 | 0.75 | KMT2A (0.56) | MAPTMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL1148605 | 0.75 | HTR2B (0.62) | MAPTHTR2BMEN1TP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL9400513 | 0.75 | HTR2C (0.67) | MAPTHTR2BMEN1TP53CYP1A2 | |
| SCHEMBL30504235 | 0.75 | MAPT (0.62) | MAPTHTR2BMEN1TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| CN-114920703-A | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2022-08-19 | — | — | CN | disclosed |