Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.49 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29757932 | 0.85 | RAB9A (0.56) | KMT2ARAB9AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL21750906 | 0.85 | RAB9A (0.56) | KMT2ARAB9AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL21750979 | 0.84 | MAOA (0.61) | KMT2ARAB9AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL29757943 | 0.84 | MAOA (0.61) | KMT2ARAB9AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL26697200 | 0.82 | GRIK1 (0.58) | KMT2ARAB9AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL26697279 | 0.82 | NPC1 (0.53) | KMT2ARAB9AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL26697254 | 0.82 | KMT2A (0.72) | KMT2AMEN1LMNAHTTALDH1A1 | |
| SCHEMBL26697260 | 0.81 | CA12 (0.64) | KMT2ARAB9AMEN1HTTMAPT | |
| SCHEMBL26697245 | 0.81 | RAB9A (0.53) | KMT2ARAB9AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL1310905 | 0.80 | MAOA (0.67) | KMT2ARAB9AMEN1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114920703-B | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2024-01-09 | — | — | CN | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| CN-114920703-A | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2022-08-19 | — | — | CN | disclosed |