Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | FPR2 | P25090 | 3/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.33 |
| ▸ | FAAH | O00519 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | AADAC | P22760 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL507802 | 0.97 | CHRM1 (0.72) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL13358956 | 0.87 | CHRM1 (0.79) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| Pretomanid SCHEMBL2983011 | 0.87 | CHRM1 (1.00) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| Pretomanid SCHEMBL14004006 | 0.87 | CHRM1 (1.00) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL508066 | 0.84 | CHRM1 (0.94) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL507542 | 0.84 | CHRM1 (0.94) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL1160458 | 0.84 | CHRM1 (0.94) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL1227110 | 0.83 | CHRM1 (0.68) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL1227767 | 0.83 | CHRM1 (0.68) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL1229184 | 0.83 | CHRM1 (0.68) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12251372-B2 | Antileishmanial compounds, compositions and use thereof | TRUSTEES OF BOSTON UNIVERSITY | 2025-03-18 | — | — | US | disclosed |
| US-20230381142-A1 | ANTILEISHMANIAL COMPOUNDS, COMPOSITIONS AND USE THEREOF | TRUSTEES OF BOSTON UNIVERSITY (US) | 2023-11-30 | — | — | US | disclosed |
| WO-2023230217-A1 | ANTILEISHMANIAL COMPOUNDS, COMPOSITIONS AND USE THEREOF | TRUSTEES OF BOSTON UNIVERSITY (US) | 2023-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230381142-A1 | ANTILEISHMANIAL COMPOUNDS, COMPOSITIONS AND USE THEREOF | MPO, SSB, SGMS2 | CHRM1 3109/4885KCNH2 3964/4885PTGS1 1334/4885 |
| US-12251372-B2 | Antileishmanial compounds, compositions and use thereof | MPO, SSB, SGMS2 | CHRM1 3109/4885KCNH2 3964/4885PTGS1 1334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.