Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2669961 | 0.92 | MEN1 (0.35) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2669769 | 0.85 | NAMPT (0.36) | ALDH1A1MEN1KMT2ASMN1; SMN2PIK3CB | |
| SCHEMBL9070790 | 0.85 | NAMPT (0.34) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2669893 | 0.84 | PRSS1 (0.35) | KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL2669960 | 0.84 | GCG (0.40) | ALDH1A1MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL2669895 | 0.83 | ESR1 (0.42) | MEN1KMT2ASMN1; SMN2TP53TSHR | |
| SCHEMBL2669989 | 0.83 | NAMPT (0.35) | ALDH1A1MEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL2669834 | 0.82 | GCG (0.41) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL13069831 | 0.81 | NPC1 (0.33) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL2669896 | 0.81 | TP53 (0.42) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251326-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009110520-A1 | HETEROCYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2009-09-11 | — | — | WO | disclosed |