Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.46 |
| ▸ | GNAI3 | P08754 | 4/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26706354 | 1.00 | HRH3 (0.46) | HRH3GNAI3GNAI1L3MBTL1KDM4E | |
| SCHEMBL26700717 | 0.94 | HRH3 (0.48) | HRH3GNAI3GNAI1L3MBTL1KDM4E | |
| SCHEMBL23735638 | 0.86 | L3MBTL1 (0.56) | L3MBTL1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL26700706 | 0.82 | HRH3 (0.43) | HRH3L3MBTL1KDM4EALDH1A1MEN1 | |
| SCHEMBL17561993 | 0.81 | GNAI3 (0.63) | HRH3GNAI3GNAI1L3MBTL1MEN1 | |
| SCHEMBL23730018 | 0.81 | HRH3 (0.47) | HRH3GNAI3GNAI1L3MBTL1KDM4E | |
| SCHEMBL18195128 | 0.81 | GNAI3 (0.63) | HRH3GNAI3GNAI1L3MBTL1MEN1 | |
| SCHEMBL20413347 | 0.80 | KDM4E (0.51) | HRH3L3MBTL1KDM4EALDH1A1MEN1 | |
| SCHEMBL24846722 | 0.80 | HRH3 (0.46) | HRH3GNAI3GNAI1L3MBTL1KDM4E | |
| SCHEMBL25443830 | 0.80 | HRH3 (0.46) | HRH3GNAI3GNAI1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215471-A1 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. (US) | 2023-11-09 | — | — | WO | disclosed |