SCHEMBL26752007

SCHEMBL26752007

CC(C)(C)[Si](C)(C)OCCc1nc(Br)c[nH]1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 3/20 0.33
DUT P33316 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29111658 0.75 DUT (0.32) DUT
SCHEMBL26752005 0.73 DUT (0.34) DUT
SCHEMBL18839726 0.71 TERT (0.40) DUT
SCHEMBL18758330 0.70 DUT (0.31) DUT
SCHEMBL21962140 0.70 SMN1; SMN2 (0.33) DUT
SCHEMBL17544454 0.70 DUT (0.33) DUT
SCHEMBL10005124 0.69 HTR7 (0.36) DUT
SCHEMBL6114675 0.68 DUT (0.34) DUT
SCHEMBL26752020 0.68 DUT (0.35) DUT
SCHEMBL9026862 0.68 DUT (0.41) HRH3DUT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115996932-A New macrocyclic LRRK2 kinase inhibitors 法国施维雅药厂 2023-04-21 CN disclosed
EP-4146658-A1 NEW MACROCYCLIC LRRK2 KINASE INHIBITORS Les Laboratoires Servier (FR) 2023-03-15 EP disclosed