Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 20/20 | 1.00 |
| ▸ | NOS3 | P29474 | 18/20 | 1.00 |
| ▸ | NOS2 | P35228 | 13/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2675019 | 0.94 | NOS3 (0.98) | NOS1NOS3NOS2KCNH2 | |
| Hydrochloric Acid SCHEMBL2677351 | 0.92 | NOS3 (1.00) | NOS1NOS3NOS2KCNH2 | |
| SCHEMBL2675199 | 0.88 | NOS1 (0.98) | NOS1NOS3NOS2KCNH2 | |
| SCHEMBL2677054 | 0.86 | NOS3 (0.98) | NOS1NOS3NOS2KCNH2 | |
| SCHEMBL2674990 | 0.86 | NOS3 (0.84) | NOS1NOS3NOS2KCNH2 | |
| SCHEMBL2676601 | 0.85 | NOS3 (0.98) | NOS1NOS3NOS2KCNH2 | |
| SCHEMBL2676562 | 0.84 | NOS1 (1.00) | NOS1NOS3NOS2 | |
| SCHEMBL2676868 | 0.84 | NOS3 (0.98) | NOS1NOS3NOS2KCNH2 | |
| SCHEMBL499445 | 0.84 | NOS3 (1.00) | NOS1NOS3NOS2 | |
| SCHEMBL2674978 | 0.83 | NOS1 (0.98) | NOS1NOS3NOS2KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173813-B2 | selectively inhibit neuronal nitric oxide synthase in combination with other pharmaceutically active agents; antidepressants | NEURAXON, INC. (CA) | 2012-05-08 | — | — | US | disclosed |
| CN-101679397-A | Quinolone and tetrahydroquinoline having NOS inhibitory activity and related compounds | NEURAXON INC | 2010-03-24 | — | — | CN | disclosed |
| US-20080234237-A1 | QUINOLONE AND TETRAHYDROQUINOLONE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234237-A1 | QUINOLONE AND TETRAHYDROQUINOLONE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NOS1, NOS2, NOS3 | NOS1 1/4885NOS3 3/4885NOS2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.