Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 8/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20722382 | 0.91 | PRCP (0.53) | PRCPGAARECQLGID4MAPT | |
| SCHEMBL4399590 | 0.86 | GAA (0.54) | PRCPGAARECQLGID4MAPT | |
| SCHEMBL6986104 | 0.79 | PRCP (0.52) | PRCPGAARECQLGID4MAPT | |
| SCHEMBL26116236 | 0.79 | RECQL (0.52) | PRCPGAARECQLGID4MAPT | |
| SCHEMBL4120535 | 0.79 | PRCP (0.50) | PRCPGAARECQLGID4MAPT | |
| SCHEMBL23274866 | 0.76 | PRCP (0.61) | PRCPGAARECQLGID4MAPT | |
| SCHEMBL29924130 | 0.76 | PRCP (0.61) | PRCPGAARECQLGID4MAPT | |
| SCHEMBL3068128 | 0.76 | PRCP (0.54) | PRCPGAARECQLGID4HTR2A | |
| SCHEMBL6185636 | 0.75 | PRCP (0.60) | PRCPGAASLC22A1SMN1; SMN2 | |
| SCHEMBL6229660 | 0.75 | PRCP (0.65) | PRCPGAARECQLGID4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4659812-A1 | DETECTION METHODS AND COMBINATION THERAPIES OF CELLS WITH EXTRACELLULAR RAS EXPRESSION | Bumm, Thomas (DE) | 2025-12-10 | — | — | EP | disclosed |
| US-20230132973-A1 | DIHYDRO-SPIRO[INDOLINE-3:1'-iSOQUINOLIN]-2-ONES AS ANTIMALARIAL AGENTS | THE UNIV OF BUEA (CM) | 2023-05-04 | — | — | US | disclosed |
| WO-2021186348-A1 | DIHYDRO-SPIRO[INDOLINE-3:1'-ISOQUINOLIN]-2-ONES AS ANTIMALARIAL AGENTS | THE UNIVERSITY OF BUEA (CM) | 2021-09-23 | — | — | WO | disclosed |
| EP-2074100-B1 | BIOFILM-INHIBITING EFFECT AND ANTI-INFECTIVE ACTIVITY OF N,C-LINKED ARYLISOQUINOLINES AND THE USE THEREOF | UNIV WUERZBURG J MAXIMILIANS (DE) | 2013-08-28 | — | — | EP | disclosed |
| US-8173673-B2 | Biofilm-inhibiting effect and anti-infective activity of N,C-linked aryl isoquinolines and the use thereof | JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG (DE) | 2012-05-08 | — | — | US | disclosed |
| US-20100286198-A1 | Biofilm-Inhibiting Effect and Anti-Infective Activity of N,C- Linked Arylisoquinolines and the Use Thereof | JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG (DE) | 2010-11-11 | — | — | US | disclosed |
| EP-2074100-A1 | BIOFILM-INHIBITING EFFECT AND ANTI-INFECTIVE ACTIVITY OF N,C-LINKED ARYLISOQUINOLINES AND THE USE THEREOF | Julius-Maximilians-Universität Würzburg (DE) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008037482-A1 | BIOFILM-INHIBITING EFFECT AND ANTI-INFECTIVE ACTIVITY OF N,C-LINKED ARYLISOQUINOLINES AND THE USE THEREOF | JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG (DE) | 2008-04-03 | — | — | WO | disclosed |
| EP-1045837-B1 | MONOMERIC AND DIMERIC ARYLISOQUINOLINE ALKALOIDS AND DERIVATIVES THEREOF | US GOV HEALTH & HUMAN SERV (US) | 2007-03-14 | — | — | EP | disclosed |
| US-6331630-B1 | Dimeric arylisoquinoline alkaloids and derivatives thereof | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2001-12-18 | — | — | US | disclosed |
| US-6140339-A | Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2000-10-31 | — | — | US | disclosed |
| EP-1045837-A1 | MONOMERIC AND DIMERIC ARYLISOQUINOLINE ALKALOIDS AND DERIVATIVES THEREOF | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999033811-A1 | MONOMERIC AND DIMERIC ARYLISOQUINOLINE ALKALOIDS AND DERIVATIVES THEREOF | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, R EPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1999-07-08 | — | — | WO | disclosed |
| EP-0745066-A1 | ANTIMALARIAL KORUPENSAMINES AND PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995021826-A1 | ANTIMALARIAL KORUPENSAMINES AND PHARMACEUTICAL COMPOSITIONS AND MEDICAL USES THEREOF | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1995-08-17 | — | — | WO | disclosed |
| US-5409938-A | A plant extracts having a naphthyl-tetrahydroisoquinolines group; a new drug treating malarial, parasiticides | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1995-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286198-A1 | Biofilm-Inhibiting Effect and Anti-Infective Activity of N,C- Linked Arylisoquinolines and the Use Thereof | PGLS, NACA, PFAS | PRCP 1603/4885GAA 668/4885RECQL 478/4885 |
| US-20230132973-A1 | DIHYDRO-SPIRO[INDOLINE-3:1'-iSOQUINOLIN]-2-ONES AS ANTIMALARIAL AGENTS | QDPR, NQO1, IDO2 | PRCP 2729/4885GAA 3964/4885RECQL 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.