Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 2/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397677 | 0.79 | CA2 (0.37) | DGAT1MAOAMAOBMEN1GAA | |
| SCHEMBL13460765 | 0.77 | EGLN1 (0.41) | DGAT1MEN1GAAKMT2AEGLN1 | |
| SCHEMBL19709584 | 0.74 | PHF8 (0.35) | DGAT1MEN1GAAKMT2AEGLN1 | |
| SCHEMBL10423501 | 0.73 | HSD17B10 (0.41) | EGLN1TDP1 | |
| SCHEMBL25036206 | 0.73 | MAOA (0.34) | MAOAMAOB | |
| SCHEMBL8206554 | 0.73 | CA2 (0.33) | DGAT1MAOAMAOBMEN1GAA | |
| SCHEMBL13742870 | 0.72 | — | — | |
| SCHEMBL3657317 | 0.72 | CA2 (0.37) | DGAT1MAOAMAOBMEN1GAA | |
| SCHEMBL8056143 | 0.71 | EGLN1 (0.44) | DGAT1MAOAMAOBMEN1GAA | |
| SCHEMBL2139565 | 0.71 | MAOA (0.39) | DGAT1MAOAMAOBMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023214576-A1 | CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS | 中外製薬株式会社 | 2023-11-09 | — | — | WO | disclosed |