Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 8/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.35 |
| ▸ | CASP6 | P55212 | 2/20 | 0.35 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26779258 | 0.89 | PSMB5 (0.41) | KDM4EHTTPSMB5MAPK1LMNA | |
| SCHEMBL26773187 | 0.85 | KDM4E (0.49) | KDM4EALDH1A1HTTMAPTPSMB5 | |
| SCHEMBL956347 | 0.78 | KDM4E (0.46) | KDM4EALDH1A1HTTMAPTNLRP3 | |
| SCHEMBL26779100 | 0.71 | CA12 (0.42) | KDM4EALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL22307837 | 0.70 | KDM4E (0.55) | KDM4EALDH1A1HTTMAPTCASP3 | |
| SCHEMBL22308325 | 0.68 | MAPT (0.49) | KDM4EALDH1A1HTTMAPTCASP3 | |
| SCHEMBL9368682 | 0.68 | NLRP3 (0.40) | MAPTNLRP3CASP7MAPK1L3MBTL1 | |
| SCHEMBL22307313 | 0.67 | MAPT (0.56) | KDM4EALDH1A1HTTMAPTCASP3 | |
| SCHEMBL25985226 | 0.67 | KDM4E (0.52) | KDM4EALDH1A1HTTMAPTCASP3 | |
| SCHEMBL11293873 | 0.67 | TAS1R3 (0.38) | KDM4EALDH1A1HTTMAPTNLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215559-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | ARIA PHARMACEUTICALS, INC. (US) | 2023-11-09 | — | — | WO | disclosed |