Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 5/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | RXRB | P28702 | 2/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.30 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.30 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12529424 | 0.85 | HDAC6 (0.43) | HSD17B1HSD17B2KIF11MAPK14RXRA | |
| SCHEMBL12529444 | 0.76 | DYRK1A (0.62) | KIF11CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL12632147 | 0.75 | KIF11 (0.50) | KIF11CYP3A4CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL14817169 | 0.75 | TSHR (0.38) | HSD17B1HSD17B2KIF11CCR4TSHR | |
| SCHEMBL12529448 | 0.74 | ALAD (0.47) | MAPK14CNR1CYP1A2 | |
| SCHEMBL18858485 | 0.74 | ALAD (0.47) | HSD17B1HSD17B2KIF11CYP2A6 | |
| SCHEMBL26781848 | 0.72 | CYP2A6 (0.36) | CYP1A1CYP2A6CYP1B1 | |
| SCHEMBL12632125 | 0.72 | PDE10A (0.42) | CYP2D6CYP2C19CYP2C9CYP1A2CYP2A6 | |
| SCHEMBL24037301 | 0.69 | COMT (0.36) | HSD17B1HSD17B2KIF11TSHRRECQL | |
| SCHEMBL24037300 | 0.69 | HRH4 (0.36) | HSD17B1HSD17B2KIF11CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11814379-B2 | Cyano quinoline amide compounds as HER2 inhibitors and methods of use | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11814379-B2 | Cyano quinoline amide compounds as HER2 inhibitors and methods of use | ERBB2, EGFR, ERBB3 | HSD17B1 4000/4885HSD17B2 3570/4885KIF11 3905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.