Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26783447 | 0.83 | BRAF (0.37) | ALDH1A1LMNAGAAJAK3MEN1 | |
| SCHEMBL23592426 | 0.80 | GRM5 (0.46) | GRM5CLK4ACVR1CLK2CDK8 | |
| SCHEMBL26783470 | 0.79 | AR (0.47) | CLK4CLK2NPC1TP53RAB9A | |
| SCHEMBL23593416 | 0.77 | KDM4E (0.43) | NPC1RAB9AGAAPOLBMEN1 | |
| SCHEMBL23593325 | 0.76 | MAPT (0.38) | NPC1RAB9AMETLMNAGAA | |
| SCHEMBL23593322 | 0.75 | POLB (0.48) | NPC1RAB9AMETALDH1A1POLB | |
| SCHEMBL24118250 | 0.75 | ALDH1A1 (0.54) | RAB9AALDH1A1LMNAPOLBMEN1 | |
| SCHEMBL23593377 | 0.74 | MAPT (0.42) | NPC1TP53RAB9AGAAPOLB | |
| SCHEMBL24118232 | 0.74 | EPHX2 (0.43) | POLBMEN1CYP2C9CYP2C19KMT2A | |
| SCHEMBL24118254 | 0.73 | FPR2 (0.48) | RAB9AALDH1A1LMNAPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810116-B1 | NOVEL SUBSTITUTED [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-11-15 | — | — | EP | disclosed |