Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 12/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 12/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.34 |
| ▸ | CLK1 | P49759 | 2/20 | 0.34 |
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2678527 | 0.92 | MTNR1A (0.39) | MTNR1AMTNR1BHDAC3NCOR1HDAC2 | |
| SCHEMBL2678412 | 0.90 | MTNR1A (0.40) | MTNR1AMTNR1BHDAC3NCOR1HDAC2 | |
| SCHEMBL2678111 | 0.90 | MTNR1A (0.40) | MTNR1AMTNR1BHDAC3NCOR1HDAC2 | |
| SCHEMBL6128583 | 0.87 | HDAC3 (0.35) | MTNR1AMTNR1BHDAC3NCOR1HDAC2 | |
| SCHEMBL2678816 | 0.85 | JAK2 (0.39) | MTNR1AMTNR1B | |
| SCHEMBL2679375 | 0.84 | HDAC3 (0.41) | HDAC3NCOR1HDAC2GSK3BDYRK1A | |
| SCHEMBL2679402 | 0.83 | MAPK9 (0.37) | MTNR1AMTNR1BHDAC3NCOR1HDAC2 | |
| SCHEMBL2679029 | 0.83 | SYK (0.48) | MTNR1AMTNR1B | |
| SCHEMBL2678213 | 0.83 | ACHE (0.42) | — | |
| SCHEMBL2678820 | 0.82 | MEN1 (0.42) | HDAC3NCOR1HDAC2GSK3BPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173808-B2 | Substituted naphthalenyl-pyrimidine compounds | ARQULE, INC. (US) | 2012-05-08 | — | — | US | claimed |