Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.75 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TPMT | P51580 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NQO1 | P15559 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aristolochic D SCHEMBL29588367 | 1.00 | CDK2 (1.00) | CDK2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| Aristolochic Acid Iv SCHEMBL29238593 | 0.90 | CDK2 (0.82) | CDK2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| Aristolochic Acid SCHEMBL29518476 | 0.86 | ALDH1A1 (1.00) | CDK2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| Aristolochic Acid SCHEMBL29367530 | 0.86 | ALDH1A1 (1.00) | CDK2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| Aristolochic Acid SCHEMBL30825061 | 0.86 | ALDH1A1 (1.00) | CDK2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| Aristolochic Acid SCHEMBL166284 | 0.86 | ALDH1A1 (1.00) | CDK2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| Aristolochic Acid SCHEMBL15535358 | 0.85 | ALDH1A1 (0.98) | CDK2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| 7-Hydroxy Aristolochic A SCHEMBL4557492 | 0.81 | CDK2 (1.00) | CDK2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| Aristolochic Acid C SCHEMBL30039516 | 0.79 | CDK2 (1.00) | CDK2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| Aristolochic Acid C SCHEMBL30697302 | 0.79 | CDK2 (1.00) | CDK2MEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230372288-A1 | Application of Aristolochic Acid IVa in Preparation of Antihistamine or Drug for Treating Pneumonia | INSTITUTE OF CHINESE MATERIA MEDICA, CHINA ACADEMY OF CHINESE MEDICAL SCIENCES (CN) | 2023-11-23 | — | — | US | disclosed |
| CN-115969840-A | Application of aristolochic acid IVa in preparing medicine for treating autoimmune disease | 上海交通大学医学院 | 2023-04-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230372288-A1 | Application of Aristolochic Acid IVa in Preparation of Antihistamine or Drug for Treating Pneumonia | HRH4, HRH3, HRH2 | CDK2 2978/4885MEN1 4773/4885KMT2A 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.