Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.65 |
| ▸ | RIPK3 | Q9Y572 | 4/20 | 0.65 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.65 |
| ▸ | AXL | P30530 | 7/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.50 |
| ▸ | MERTK | Q12866 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL783423 | 0.91 | MET (0.65) | METRIPK3RIPK1RIPK2AXL | |
| SCHEMBL783496 | 0.89 | AXL (0.55) | METRIPK3RIPK1RIPK2AXL | |
| SCHEMBL783531 | 0.84 | MET (0.71) | METRIPK3RIPK1RIPK2AXL | |
| SCHEMBL1137050 | 0.81 | MET (0.89) | METRIPK3RIPK1RIPK2AXL | |
| SCHEMBL12350035 | 0.76 | MET (0.74) | METRIPK3RIPK1RIPK2AXL | |
| SCHEMBL12350063 | 0.76 | MET (0.74) | METRIPK3RIPK1RIPK2AXL | |
| SCHEMBL12350024 | 0.76 | MET (0.74) | METRIPK3RIPK1RIPK2AXL | |
| SCHEMBL2742632 | 0.76 | MET (0.77) | METAXLKDRLCKKIT | |
| SCHEMBL199864 | 0.76 | AXL (0.61) | METRIPK3RIPK1RIPK2AXL | |
| SCHEMBL1471850 | 0.76 | MET (0.59) | METRIPK3RIPK1RIPK2AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088794-B2 | Substituted amide derivatives and methods of use | AMGEN INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20110118252-A1 | SUBSTITUTED AMIDE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118252-A1 | SUBSTITUTED AMIDE DERIVATIVES AND METHODS OF USE | HGF, HGFAC, MET | MET 3/4885RIPK3 3408/4885RIPK1 3769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.