Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 5/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 5/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | GUSB | P08236 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26808371 | 0.92 | MAPT (0.41) | HTR6HTR1ADRD2HTR7MAPK10 | |
| SCHEMBL26807343 | 0.92 | HTR6 (0.38) | HTR6HTR1ADRD2HTR7RIPK2 | |
| SCHEMBL29566834 | 0.92 | HTR6 (0.38) | HTR6HTR1ADRD2HTR7RIPK2 | |
| SCHEMBL26807316 | 0.90 | RIPK2 (0.39) | HTR6HTR1AHTR7RIPK2NOD2 | |
| SCHEMBL29566726 | 0.90 | RIPK2 (0.39) | HTR6HTR1AHTR7RIPK2NOD2 | |
| SCHEMBL24310301 | 0.89 | GUSB (0.37) | HTR6RIPK2NOD2ACVR1FLT3 | |
| SCHEMBL29566475 | 0.89 | GUSB (0.37) | HTR6RIPK2NOD2ACVR1FLT3 | |
| SCHEMBL26807468 | 0.89 | GUSB (0.42) | HTR6RIPK2NOD2ACVR1FLT3 | |
| SCHEMBL29567073 | 0.88 | HTR1A (0.43) | HTR6HTR1ADRD2HTR7HTR2A | |
| SCHEMBL24309659 | 0.88 | HTR1A (0.43) | HTR6HTR1ADRD2HTR7HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1G, SCNN1B | HTR6 2653/4885HTR1A 4018/4885DRD2 4505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.