Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 5/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 5/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GUSB | P08236 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26807316 | 1.00 | RIPK2 (0.39) | RIPK2ACVR1NOD2HTR6FLT3 | |
| SCHEMBL26807466 | 0.94 | FLT3 (0.38) | RIPK2ACVR1NOD2HTR6FLT3 | |
| SCHEMBL26807468 | 0.91 | GUSB (0.42) | RIPK2ACVR1NOD2HTR6FLT3 | |
| SCHEMBL24310583 | 0.91 | RIPK2 (0.38) | RIPK2ACVR1NOD2HTR6FLT3 | |
| SCHEMBL26807463 | 0.91 | ACVR1 (0.40) | RIPK2ACVR1NOD2HTR6GUSB | |
| SCHEMBL26808355 | 0.90 | HTR6 (0.39) | RIPK2ACVR1NOD2HTR6FLT3 | |
| SCHEMBL26807460 | 0.89 | HTR6 (0.43) | RIPK2ACVR1NOD2HTR6FLT3 | |
| SCHEMBL29566865 | 0.89 | GUSB (0.39) | RIPK2ACVR1NOD2HTR6FLT3 | |
| SCHEMBL24309665 | 0.89 | GUSB (0.39) | RIPK2ACVR1NOD2HTR6FLT3 | |
| SCHEMBL26807465 | 0.89 | ACVR1 (0.39) | RIPK2ACVR1NOD2HTR6FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |