Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | OGA | O60502 | 3/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24827889 | 0.81 | CYP3A4 (0.36) | CYP3A4CYP2D6TSHRMEN1KMT2A | |
| SCHEMBL12771442 | 0.80 | ACHE (0.45) | GPR119PANK3ALDH1A1OGAACHE | |
| SCHEMBL24827911 | 0.78 | CYP3A4 (0.35) | CYP3A4CYP2D6TSHRMEN1KMT2A | |
| SCHEMBL26844919 | 0.75 | ACACB (0.36) | CYP3A4CYP2D6TSHRMEN1KMT2A | |
| SCHEMBL26846118 | 0.75 | OGA (0.39) | CYP3A4CYP2D6TSHRMEN1KMT2A | |
| SCHEMBL26845645 | 0.74 | OPRM1 (0.43) | CYP3A4CYP2D6TSHRMEN1KMT2A | |
| SCHEMBL13466910 | 0.73 | PANK3 (0.40) | TSHRPANK3ALDH1A1OGAACACB | |
| SCHEMBL19105574 | 0.73 | PANK3 (0.40) | PANK3HPGDOGAACACBSMN1; SMN2 | |
| SCHEMBL16131123 | 0.72 | POLB (0.42) | TSHRMEN1KMT2APANK3ALDH1A1 | |
| SCHEMBL23483105 | 0.71 | ALDH1A1 (0.42) | TSHRMEN1KMT2APANK3HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2023220137-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |