Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | FGR | P09769 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | CSK | P41240 | 1/20 | 0.41 |
| ▸ | BLK | P51451 | 1/20 | 0.41 |
| ▸ | BMX | P51813 | 1/20 | 0.41 |
| ▸ | SRMS | Q9H3Y6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2682252 | 0.94 | SLC2A1 (0.51) | METMAP4K4SLC2A1MAPK1MINK1 | |
| Trifluoroacetic Acid SCHEMBL1078545 | 0.89 | SLC2A1 (0.50) | METMAP4K4SLC2A1MAPK1NPBWR1 | |
| SCHEMBL2681943 | 0.84 | MAP4K4 (0.62) | METMAP4K4SLC2A1MAPK1NPBWR1 | |
| SCHEMBL2680251 | 0.83 | MAP4K4 (0.52) | METMAP4K4SLC2A1MAPK1NPBWR1 | |
| Trifluoroacetic Acid SCHEMBL2681122 | 0.83 | MET (0.49) | METMAP4K4MAPK1YES1 | |
| SCHEMBL1078643 | 0.82 | SLC2A1 (0.55) | METMAP4K4SLC2A1MAPK1NPBWR1 | |
| Trifluoroacetic Acid SCHEMBL1043431 | 0.81 | MET (0.48) | METMAP4K4MAPK1YES1 | |
| Trifluoroacetic Acid SCHEMBL1045539 | 0.81 | MET (0.51) | METMAP4K4SLC2A1MAPK1NPBWR1 | |
| SCHEMBL4258499 | 0.81 | MAP4K4 (0.53) | METMAP4K4MAPK1ABL1PDPK1 | |
| SCHEMBL2680839 | 0.80 | CDK2 (0.62) | METMAP4K4SLC2A1NPBWR1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648201-B2 | Aminopyridine derivatives for treating tumors and inflammatory diseases | MERCK PATENT GMBH (DE) | 2014-02-11 | — | — | US | disclosed |
| US-20120115861-A1 | AMINOPYRIDINE DERIVATIVES FOR TREATING TUMORS AND INFLAMMATORY DISEASES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115861-A1 | AMINOPYRIDINE DERIVATIVES FOR TREATING TUMORS AND INFLAMMATORY DISEASES | PDK1, PDK2, PDK4 | MET 3052/4885MAP4K4 145/4885SLC2A1 890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.