SCHEMBL268185

SCHEMBL268185

Cc1ccc(C=NNC(=O)c2c(C)csc2NC(=O)c2cccc(CN3CCC(N4CCCCC4)CC3)c2)cc1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC34A2 O95436 5/20 0.49
CYP3A4 P08684 1/20 0.41
MAPT P10636 1/20 0.41
CYP2C9 P11712 1/20 0.41
ACKR3 P25106 2/20 0.40
MEN1 O00255 2/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
KMT2A Q03164 2/20 0.40
MBTD1 Q05BQ5 1/20 0.39
L3MBTL3 Q96JM7 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL273733 1.00 SLC34A2 (0.49) SLC34A2CYP3A4MAPTCYP2C9ACKR3
SCHEMBL273735 0.94 SLC34A2 (0.49) SLC34A2CYP3A4MAPTCYP2C9ACKR3
SCHEMBL268995 0.94 SLC34A2 (0.49) SLC34A2CYP3A4MAPTCYP2C9ACKR3
SCHEMBL273730 0.94 SLC34A2 (0.50) SLC34A2CYP3A4MAPTCYP2C9ACKR3
SCHEMBL266272 0.94 SLC34A2 (0.50) SLC34A2CYP3A4MAPTCYP2C9ACKR3
SCHEMBL267715 0.93 SLC34A2 (0.47) SLC34A2CYP3A4MAPTCYP2C9ACKR3
SCHEMBL273736 0.93 SLC34A2 (0.47) SLC34A2CYP3A4MAPTCYP2C9ACKR3
SCHEMBL267306 0.91 SLC34A2 (0.49) SLC34A2CYP3A4ACKR3MEN1NPC1
SCHEMBL274311 0.91 SLC34A2 (0.49) SLC34A2CYP3A4ACKR3MEN1NPC1
SCHEMBL267682 0.90 SLC34A2 (0.57) SLC34A2ACKR3MEN1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-05-10 US disclosed
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 US disclosed
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-28 US disclosed
EP-1614676-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-01-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same SLC10A6, SLC7A1, SLC10A1 SLC34A2 6/4885CYP3A4 1856/4885MAPT 4195/4885
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME SLC34A1, SLC34A2, SLC20A2 SLC34A2 2/4885CYP3A4 1849/4885MAPT 4648/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.