SCHEMBL268995

SCHEMBL268995

Cc1csc(NC(=O)c2cccc(CN3CCC(N4CCCCC4)CC3)c2)c1C(=O)NN=Cc1ccc(F)cc1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC34A2 O95436 5/20 0.49
L3MBTL1 Q9Y468 1/20 0.43
RAB9A P51151 3/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
NPC1 O15118 2/20 0.42
GAA P10253 1/20 0.41
CYP3A4 P08684 1/20 0.40
MAPT P10636 1/20 0.40
CYP2C9 P11712 1/20 0.40
ACKR3 P25106 2/20 0.39
ENPP2 Q13822 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL273735 1.00 SLC34A2 (0.49) SLC34A2L3MBTL1RAB9AMEN1KMT2A
SCHEMBL268185 0.94 SLC34A2 (0.49) SLC34A2RAB9AMEN1KMT2ANPC1
SCHEMBL273733 0.94 SLC34A2 (0.49) SLC34A2RAB9AMEN1KMT2ANPC1
SCHEMBL274311 0.94 SLC34A2 (0.49) SLC34A2RAB9AMEN1KMT2ANPC1
SCHEMBL267306 0.94 SLC34A2 (0.49) SLC34A2RAB9AMEN1KMT2ANPC1
SCHEMBL273730 0.92 SLC34A2 (0.50) SLC34A2CYP3A4MAPTCYP2C9ACKR3
SCHEMBL266272 0.92 SLC34A2 (0.50) SLC34A2CYP3A4MAPTCYP2C9ACKR3
SCHEMBL273736 0.92 SLC34A2 (0.47) SLC34A2RAB9AKMT2ANPC1CYP3A4
SCHEMBL267715 0.92 SLC34A2 (0.47) SLC34A2RAB9AKMT2ANPC1CYP3A4
SCHEMBL266832 0.91 SLC34A2 (0.57) SLC34A2L3MBTL1RAB9AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-05-10 US disclosed
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 US disclosed
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-28 US disclosed
EP-1614676-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-01-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same SLC10A6, SLC7A1, SLC10A1 SLC34A2 6/4885L3MBTL1 934/4885RAB9A 883/4885
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME SLC34A1, SLC34A2, SLC20A2 SLC34A2 2/4885L3MBTL1 1096/4885RAB9A 1362/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.