Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORA | P35398 | 1/20 | 0.40 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.35 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2683768 | 1.00 | RORA (0.40) | RORANR2E1AAK1MAPK1CYP2C9 | |
| SCHEMBL2686183 | 0.94 | PTGER1 (0.40) | RORANR2E1AAK1MAPK1CYP2C9 | |
| SCHEMBL2686188 | 0.94 | PTGER1 (0.40) | RORANR2E1AAK1MAPK1CYP2C9 | |
| SCHEMBL13258426 | 0.87 | AAK1 (0.41) | RORANR2E1AAK1MAPK1PSEN1 | |
| SCHEMBL13258419 | 0.81 | AAK1 (0.41) | RORANR2E1AAK1MAPK1CYP2C9 | |
| SCHEMBL2685599 | 0.77 | HDAC8 (0.45) | RORANR2E1MAPK1CYP2C9CYP3A4 | |
| SCHEMBL2685594 | 0.77 | HDAC8 (0.45) | RORANR2E1MAPK1CYP2C9CYP3A4 | |
| SCHEMBL2685745 | 0.70 | IDO1 (0.47) | CYP2C9CYP3A4CYP2D6IDO1L3MBTL1 | |
| SCHEMBL2685750 | 0.70 | IDO1 (0.47) | CYP2C9CYP3A4CYP2D6IDO1L3MBTL1 | |
| SCHEMBL2687188 | 0.67 | CCNC (0.44) | AAK1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785468-B2 | Phenylalanine amide derivatives useful for treating insulin-related diseases and conditions | AMGEN INC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20120115811-A1 | PHENYLANALINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS | AMGEN INC. (US) | 2012-05-10 | — | — | US | disclosed |
| WO-2010093849-A2 | PHENYLALANINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS | AMGEN INC. (US) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115811-A1 | PHENYLANALINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS | IAPP, INSR, AMY2A | RORA 3188/4885NR2E1 390/4885AAK1 1582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.