Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.59 |
| ▸ | ACLY | P53396 | 7/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21218304 | 0.89 | CRBN (0.60) | CRBNACLYRXFP1PTGES2PGR | |
| SCHEMBL26844443 | 0.85 | CRBN (0.61) | CRBNACLYRXFP1PTGES2PGR | |
| SCHEMBL26844403 | 0.81 | CRBN (0.70) | CRBNACLYRXFP1PTGES2PGR | |
| SCHEMBL21218367 | 0.80 | ACLY (0.61) | CRBNACLYRXFP1PTGES2PGR | |
| SCHEMBL26844396 | 0.78 | CRBN (0.85) | CRBNACLYRXFP1PTGES2PGR | |
| SCHEMBL1389171 | 0.77 | CRBN (0.59) | CRBNACLYRXFP1PTGES2PGR | |
| SCHEMBL26844503 | 0.76 | CRBN (0.75) | CRBNACLYRXFP1PTGES2PGR | |
| SCHEMBL21218300 | 0.75 | CRBN (0.68) | CRBNACLYRXFP1PTGES2PGR | |
| SCHEMBL21218349 | 0.75 | ACLY (0.54) | CRBNACLYRXFP1PTGES2PGR | |
| SCHEMBL26844499 | 0.75 | CRBN (0.74) | CRBNACLYRXFP1PTGES2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807606-B2 | Sulfonamide derivatives for protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11807606-B2 | Sulfonamide derivatives for protein degradation | CUL5, CUL4A, DCAF1 | CRBN 14/4885ACLY 2332/4885RXFP1 3507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.