Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 8/20 | 0.61 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.48 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21218353 | 0.84 | CRBN (0.51) | ACLYPTGES2CRBNGLO1SLC40A1 | |
| SCHEMBL24762248 | 0.82 | ACLY (0.53) | ACLYPTGES2CRBNGLO1SLC40A1 | |
| SCHEMBL29764427 | 0.82 | ACLY (0.53) | ACLYPTGES2CRBNGLO1SLC40A1 | |
| SCHEMBL21218304 | 0.81 | CRBN (0.60) | ACLYPTGES2CRBNGLO1SLC40A1 | |
| SCHEMBL26844440 | 0.80 | CRBN (0.59) | ACLYPTGES2CRBNGLO1SLC40A1 | |
| SCHEMBL21218349 | 0.80 | ACLY (0.54) | ACLYPTGES2CRBNGLO1SLC40A1 | |
| SCHEMBL21931010 | 0.76 | ACLY (1.00) | ACLYPTGES2PGR | |
| SCHEMBL21218371 | 0.76 | IKBKB (0.47) | ACLYIKBKBCHUKBRD4 | |
| SCHEMBL21218461 | 0.74 | CRBN (0.76) | ACLYPTGES2CRBNGLO1SLC40A1 | |
| SCHEMBL21999602 | 0.74 | ACLY (1.00) | ACLYPTGES2PIK3CDTRIM24MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807606-B2 | Sulfonamide derivatives for protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-11-07 | — | — | US | disclosed |
| US-11807606-B2 | Sulfonamide derivatives for protein degradation | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-11-07 | — | — | US | disclosed |
| US-20200290964-A1 | SULFONAMIDE DERIVATIVES FOR PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. | 2020-09-17 | — | — | US | disclosed |
| WO-2019147783-A1 | SULFONAMIDE DERIVATIVES FOR PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200290964-A1 | SULFONAMIDE DERIVATIVES FOR PROTEIN DEGRADATION | CUL5, CUL4A, DCAF1 | ACLY 2332/4885PTGES2 4806/4885CRBN 14/4885 |
| US-11807606-B2 | Sulfonamide derivatives for protein degradation | CUL5, CUL4A, DCAF1 | ACLY 2332/4885PTGES2 4806/4885CRBN 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.