SCHEMBL26847460

SCHEMBL26847460

CNC(=O)CSc1nc(C(F)(F)F)cc(=O)[nH]1

nearest known ligand 0.62

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ FABP4 P15090 2/20 0.60
▸ MAPT P10636 1/20 0.53
▸ FABP3 P05413 1/20 0.52
▸ KMT2A Q03164 3/20 0.51
▸ LMNA P02545 1/20 0.51
▸ TSHR P16473 1/20 0.51
▸ MEN1 O00255 2/20 0.49
▸ GLA P06280 1/20 0.49
▸ KDM4E B2RXH2 1/20 0.46
▸ ALDH1A1 P00352 1/20 0.46
▸ CA12 O43570 1/20 0.46
▸ CA1 P00915 1/20 0.46
▸ CA2 P00918 1/20 0.46
▸ CA6 P23280 1/20 0.46
▸ CA7 P43166 1/20 0.46
▸ CA9 Q16790 1/20 0.46
▸ CA13 Q8N1Q1 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24088143 0.88 FABP4 (0.61) FABP4MAPTFABP3KMT2ALMNA
SCHEMBL24087939 0.85 FABP4 (0.56) FABP4MAPTFABP3KMT2ALMNA
SCHEMBL23853477 0.83 FABP4 (0.65) FABP4MAPTFABP3KMT2AMEN1
SCHEMBL24087911 0.83 FABP4 (0.54) FABP4MAPTFABP3KMT2ALMNA
SCHEMBL26847224 0.79 FABP4 (0.60) FABP4FABP3KMT2ALMNAMEN1
SCHEMBL26847259 0.76 FABP4 (0.57) FABP4FABP3KMT2ALMNAMEN1
SCHEMBL23852981 0.76 FABP4 (0.56) FABP4MAPTFABP3KMT2AMEN1
SCHEMBL30397714 0.75 FABP4 (1.00) FABP4KMT2ATSHRMEN1KDM4E
SCHEMBL6261877 0.74 FABP4 (0.53) FABP4FABP3KMT2AMEN1
SCHEMBL8751991 0.71 MEN1 (0.52) FABP4FABP3KMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230381177-A1 INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE TES PHARMA S.R.L. (IT) 2023-11-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230381177-A1 INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE ACMSD, GLS, ALDH7A1 FABP4 3410/4885MAPT 1263/4885FABP3 3995/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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