Skepinone-L

Skepinone-L

SCHEMBL2686103

O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 20/20 1.00
MAPK13 O15264 1/20 1.00
HSPB1 P04792 1/20 1.00
HTR2A P28223 1/20 1.00
HTR2B P41595 1/20 1.00
MAPK12 P53778 1/20 1.00
MAPK11 Q15759 1/20 1.00
TMEM97 Q5BJF2 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Skepinone-L SCHEMBL20877164 1.00 MAPK14 (1.00) MAPK14MAPK13HSPB1HTR2AHTR2B
Skepinone-L SCHEMBL29527315 1.00 MAPK14 (1.00) MAPK14MAPK13HSPB1HTR2AHTR2B
Skepinone-L SCHEMBL2685836 1.00 MAPK14 (1.00) MAPK14MAPK13HSPB1HTR2AHTR2B
Skepinone-L SCHEMBL30197623 1.00 MAPK14 (1.00) MAPK14MAPK13HSPB1HTR2AHTR2B
SCHEMBL4399789 0.96 MAPK14 (1.00) MAPK14MAPK13HSPB1HTR2AHTR2B
SCHEMBL30336051 0.96 MAPK14 (1.00) MAPK14MAPK13HSPB1HTR2AHTR2B
SCHEMBL2317837 0.96 MAPK14 (1.00) MAPK14MAPK13HSPB1HTR2AHTR2B
SCHEMBL2315888 0.91 MAPK14 (1.00) MAPK14MAPK13HSPB1HTR2AHTR2B
SCHEMBL2318032 0.87 MAPK14 (1.00) MAPK14MAPK13HSPB1HTR2AHTR2B
SCHEMBL2320212 0.86 MAPK14 (1.00) MAPK14MAPK13HSPB1HTR2AHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4720261-A1 NOVEL CULTURE CONDITIONS FOR CLONAL EXPANSION OF NEPHRON PROGENITOR CELLS, GENERATION OF NEPHRON ORGANOIDS, AND RAPID AND SCALABLE MODELING OF POLYCYSTIC KIDNEY DISEASE University of Southern California (US) 2026-04-08 EP claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
WO-2024258363-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES SAHIN FIKRET (TR) 2024-12-19 WO claimed
WO-2024243567-A1 NOVEL CULTURE CONDITIONS FOR CLONAL EXPANSION OF NEPHRON PROGENITOR CELLS, GENERATION OF NEPHRON ORGANOIDS, AND RAPID AND SCALABLE MODELING OF POLYCYSTIC KIDNEY DISEASE UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2024-11-28 WO claimed
WO-2024189434-A1 USE OF NADOLOL TO TREAT PULMONARY SYMPTOMS ASSOCIATED WITH INFECTIONS WITH SARS-CoV-2 CHRONIC AIRWAY THERAPEUTICS LIMITED (AU) 2024-09-19 WO claimed
US-20240156816-A1 METHODS AND COMPOSITIONS FOR PREDICTING AND PREVENTING RELAPSE OF ACUTE LYMPHOBLASTIC LEUKEMIA DANA-FARBER CANCER INSTITUTE, INC. 2024-05-16 US claimed
US-11844800-B2 Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2023-12-19 US claimed
WO-2023196235-A1 METHODS, DEVICES, AND SYSTEMS FOR TREATING LENS PROTEIN AGGREGATION DISEASES GLAZIER ALAN NEIL (US) 2023-10-12 WO claimed
US-20230310471-A1 METHODS, DEVICES, AND SYSTEMS FOR TREATING LENS PROTEIN AGGREGATION DISEASES GLAZIER ALAN NEIL (US) 2023-10-05 US claimed
US-20230190736-A1 SMALL MOLECULE THERAPEUTICS FOR THE TREATMENT OF VIRAL INFECTIONS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-06-22 US claimed
EP-2349964-B1 DIBENZOCYCLOHEPTANONE DERIVATIVES AND PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS C A I R BIOSCIENCES GMBH (DE) 2015-09-09 EP claimed
US-8633312-B2 Dibenzocycloheptatone derivatives and pharmaceutical agents containing said compounds C-A-I-R BIOSCIENCES GMBH (DE) 2014-01-21 US claimed
US-20120115862-A1 DIBENZOCYCLOHEPTATONE DERIVATIVES AND PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS C-A-I-R BIOSCIENCES GMBH (DE) 2012-05-10 US claimed
EP-2206534-A1 Dibenzocycloheptanone derivatives und pharmaceutical agents containing these compounds c-a-i-r biosciences GmbH (DE) 2010-07-14 EP claimed
US-12599592-B2 Therapeutic small molecules for treatment of pulmonary hypertension UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2026-04-14 US disclosed
EP-4720261-A1 NOVEL CULTURE CONDITIONS FOR CLONAL EXPANSION OF NEPHRON PROGENITOR CELLS, GENERATION OF NEPHRON ORGANOIDS, AND RAPID AND SCALABLE MODELING OF POLYCYSTIC KIDNEY DISEASE University of Southern California (US) 2026-04-08 EP disclosed
CN-120899683-A Use of Skepinone-L for killing neuroblastoma cells 大连市妇女儿童医疗中心(集团) 2025-11-07 CN disclosed
US-20150056604-A1 COMPOSITIONS AND METHODS FOR PRESERVING PLATELET FUNCTION BIOVEC TRANSFUSION, LLC 2015-02-26 US disclosed
US-8633312-B2 Dibenzocycloheptatone derivatives and pharmaceutical agents containing said compounds C-A-I-R BIOSCIENCES GMBH (DE) 2014-01-21 US disclosed
US-20120115862-A1 DIBENZOCYCLOHEPTATONE DERIVATIVES AND PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS C-A-I-R BIOSCIENCES GMBH (DE) 2012-05-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12599592-B2 Therapeutic small molecules for treatment of pulmonary hypertension GSTP1, GSTK1, GSTM1 MAPK14 2659/4885MAPK13 3460/4885HSPB1 70/4885
US-20120115862-A1 DIBENZOCYCLOHEPTATONE DERIVATIVES AND PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS IL1B, NFKBIA, IL1R1 MAPK14 2812/4885MAPK13 2654/4885HSPB1 899/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.