GSTM1

Glutathione S-transferase Mu 1 · P09488 · GSTM1 on Sugi Atlas →

56 patent compounds predicted against GSTM1, 11 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Gabosin D Gabosin D (SCHEMBL30250105) 0.35 4/20
SCHEMBL5017349 SCHEMBL5017349 0.45 3/20
SCHEMBL14094693 SCHEMBL14094693 0.45 3/20
SCHEMBL30251768 SCHEMBL30251768 0.39 3/20
SCHEMBL31404499 SCHEMBL31404499 0.39 3/20
SCHEMBL487508 SCHEMBL487508 0.48 1/20
SCHEMBL9581057 SCHEMBL9581057 0.44 1/20
SCHEMBL14063393 SCHEMBL14063393 0.44 1/20
SCHEMBL14063398 SCHEMBL14063398 0.44 1/20
SCHEMBL4186791 SCHEMBL4186791 0.41 1/20
SCHEMBL26102488 SCHEMBL26102488 0.41 1/20

Clinical trials — most relevant to GSTM1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phase IIIB Extension Clinical Trial of Efficacy and Safety of GST-HG141 (Nairevir) Combined With NAs in Chronic Hepatitis B PHASE3NOT_YET_RECRUITING
To Evaluate the Efficacy, Safety and Population Pharmacokinetics of GST-HG141 in Patients With Chronic Hepatitis B (CHB) Who Have an Inadequate Response to Antiviral Drug Treatment PHASE3RECRUITING
Ibrutinib Before and After Stem Cell Transplant in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma PHASE3ACTIVE_NOT_RECRUITING
Paracetamol Toxicity in Septic Patients PHASE3SUSPENDED
Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers PHASE2RECRUITING
Effect of Gamma Tocopherol Enriched Supplementation on Response to Inhaled O3 Exposure PHASE2COMPLETED
Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers PHASE2COMPLETED
RayGel-An Alternative for Skin Care During External Beam Radiation PHASE2COMPLETED
Evaluation of Broccoli Seed and Sprout Extract for Detoxification of Carcinogens in Firefighters PHASE2ACTIVE_NOT_RECRUITING
Sulforaphane in a New Jersey (NJ) Population of Individuals With Autism PHASE2ACTIVE_NOT_RECRUITING
Neoadjuvant Chemoradiotherapy Followed By Surgery in Treating Patients With Limited-Stage Small Cell Lung Cancer PHASE1COMPLETED
Celecoxib in Preventing Colorectal Cancer in Young Patients With a Genetic Predisposition for Familial Adenomatous Polyposis PHASE1COMPLETED
Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults PHASE1COMPLETED
Pharmacokinetics and Safety of GST-HG171 Tablets in Subjects With Impaired and Normal Liver Function PHASE1COMPLETED
Safety, Tolerability and Pharmacokinetic Characteristics Evaluation on GST-HG171 Tablets PHASE1COMPLETED
Drug-Drug Interaction Study of Itraconazole With GST-HG171/Ritonavir in Healthy Participants PHASE1COMPLETED
Food Effects of GST-HG171 Tablets Combined With Ritonavir in Healthy Chinese Participants PHASE1UNKNOWN
Safety, Tolerability and Pharmacokinetic Characteristics Evaluation on GST-HG121 Tablets PHASE1UNKNOWN
Broccoli and Vascular Health Study nanCOMPLETED
Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers nanCOMPLETED
Cancer and Hearing Loss Related in Children nanCOMPLETED
The Conversion of ENcapsulated GlucorAphanin, Gut Microbiota Phylogeny and gEnotype Study (ENGAGE) nanCOMPLETED
Mechanisms of Response to Diesel Exhaust in Subjects With Asthma nanWITHDRAWN
SHMT1 Polymorphism in Parkinson's Disease, nanUNKNOWN
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
Genetic Polymorphisms in UGT1A6 and UGT2B7 in Asian Population: Association With Lung Cancer Phenotype nanUNKNOWN
Genetic Study in Patients Receiving Treatment for Hodgkin's Disease or Childhood Brain Tumor nanCOMPLETED
Effect of Tamoxifen or an Aromatase Inhibitor on Estrogen Metabolism in Women Treated for Newly Diagnosed Breast Cancer nanCOMPLETED
Oral Glutathione Supplementation on the Levels of Blood Glutathione nanCOMPLETED
Polymorphisms and Busulfan Pharmacokinetic Study nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a GSTM1 binder may also engage these)

ProteinNameSimilarity
P30116 1.000 P30116 →
Q9N0V4 1.000 Q9N0V4 →
Q9TSM5 1.000 Q9TSM5 →
P19639 1.000 P19639 →
Q9BEB0 1.000 Q9BEB0 →
P48774 1.000 P48774 →
P08010 1.000 P08010 →
Q5R8E8 1.000 Q5R8E8 →
P10649 1.000 P10649 →
P21266 1.000 P21266 →
P46409 1.000 P46409 →
Q9BEA9 1.000 Q9BEA9 →
Q9Z1B2 1.000 Q9Z1B2 →
P46439 1.000 P46439 →
Q80W21 1.000 Q80W21 →
P04905 1.000 P04905 →
Q8R5I6 1.000 Q8R5I6 →
P15626 1.000 P15626 →
P15964 1.000 P15964 →
P08009 1.000 P08009 →
P31671 1.000 P31671 →
Q5BK56 1.000 Q5BK56 →
P20136 1.000 P20136 →
Q00285 0.999 Q00285 →
Q03013 0.999 Q03013 →
Q9TSM4 0.999 Q9TSM4 →
P08515 0.999 P08515 →
P16413 0.999 P16413 →
GSTM2 Glutathione S-transferase Mu 2 0.999 landscape →
P31670 0.997 P31670 →