Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.75 |
| ▸ | HTT | P42858 | 1/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.73 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | KLK7 | P49862 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | SCD | O00767 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24729350 | 0.88 | KDM4E (0.75) | KDM4EHTTL3MBTL1ALDH1A1RXFP1 | |
| SCHEMBL29947616 | 0.88 | KDM4E (0.75) | KDM4EHTTL3MBTL1ALDH1A1RXFP1 | |
| SCHEMBL4255595 | 0.87 | KDM4E (0.73) | KDM4EHTTL3MBTL1ALDH1A1RXFP1 | |
| SCHEMBL18250799 | 0.87 | KDM4E (0.73) | KDM4EHTTL3MBTL1ALDH1A1RXFP1 | |
| SCHEMBL15063066 | 0.87 | KDM4E (0.73) | KDM4EHTTL3MBTL1ALDH1A1RXFP1 | |
| SCHEMBL2483241 | 0.86 | SCD (0.84) | KDM4EALDH1A1RXFP1SMN1; SMN2HPGD | |
| SCHEMBL13329390 | 0.85 | MAP3K5 (0.83) | KDM4EHTTL3MBTL1ALDH1A1RXFP1 | |
| SCHEMBL21376599 | 0.84 | SCD (0.64) | KDM4EHTTL3MBTL1ALDH1A1RXFP1 | |
| SCHEMBL15063079 | 0.84 | MAPT (0.73) | KDM4EHTTL3MBTL1ALDH1A1RXFP1 | |
| SCHEMBL4917462 | 0.83 | MEN1 (0.73) | KDM4EHTTL3MBTL1ALDH1A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966166-B1 | PROMOTER OF DIFFERENTIATION OF PLURIPOTENT STEM CELL INTO MYOCARDIUM, WHICH COMPRISES EGF RECEPTOR INHIBITOR | UNIV KYOTO (JP) | 2019-04-03 | — | — | EP | disclosed |
| US-9999617-B2 | Compositions for treating bacterial infections | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2018-06-19 | — | — | US | disclosed |
| US-9999617-B2 | Compositions for treating bacterial infections | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2018-06-19 | — | — | US | disclosed |
| US-20130295017-A1 | METHODS FOR SCREENING ANTIBIOTIC COMPOUNDS | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-11-07 | — | — | US | disclosed |
| US-20120122877-A1 | Compositions for Treating Bacterial Infections | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120122877-A1 | Compositions for Treating Bacterial Infections | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120115157-A1 | Methods for Screening for Antibiotic Compounds | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-05-10 | — | — | US | disclosed |
| WO-2011002951-A1 | COMPOSITIONS FOR TREATING BACTERIAL INFECTIONS | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2011-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115157-A1 | Methods for Screening for Antibiotic Compounds | ANTXR2, CLPP, MRPL21 | KDM4E 3933/4885HTT 2334/4885L3MBTL1 2452/4885 |
| US-20120122877-A1 | Compositions for Treating Bacterial Infections | CLPP, IMMT, MRPL21 | KDM4E 3168/4885HTT 4320/4885L3MBTL1 1652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.