SCHEMBL2686196

SCHEMBL2686196

CCCn1cnc2nc(-c3ccc(OC(c4cccc(C(F)(F)F)c4)C4CNC(=O)C4)cc3)[nH]c2c1=O

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ADORA2B P29275 15/20 0.42
ADORA1 P30542 8/20 0.37
FLT3 P36888 1/20 0.36
SYK P43405 1/20 0.36
AURKB Q96GD4 1/20 0.36
ADORA2A P29274 5/20 0.35
ADORA3 P0DMS8 4/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1720234 0.87 TRPA1 (0.36) ADORA2BADORA1FLT3SYKAURKB
SCHEMBL1065318 0.84 ADORA2B (0.58) ADORA2BADORA1ADORA2AADORA3
SCHEMBL1065068 0.77 ADORA2B (0.60) ADORA2BADORA1ADORA2AADORA3
SCHEMBL1081716 0.75 ADORA2B (0.58) ADORA2BADORA1ADORA2AADORA3
SCHEMBL1065416 0.75 ADORA2B (0.56) ADORA2BADORA1ADORA2AADORA3
SCHEMBL30891840 0.75 ADORA2B (0.49) ADORA2BADORA1ADORA2AADORA3
SCHEMBL2686448 0.75 ADORA2B (0.49) ADORA2BADORA1ADORA2AADORA3
SCHEMBL30891847 0.75 ADORA2B (0.74) ADORA2BADORA1ADORA2A
SCHEMBL2685092 0.75 ADORA2B (0.74) ADORA2BADORA1ADORA2A
SCHEMBL2684217 0.74 ADORA2B (0.38) ADORA2BADORA1FLT3SYKAURKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240307402-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER IMPETIS BIOSCIENCES LTD. (IN) 2024-09-19 US claimed
CN-118001282-A Pharmaceutical composition for cancer treatment 因佩蒂斯生物科学有限公司 2024-05-10 CN claimed
EP-3727391-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER Impetis Biosciences Ltd. (IN) 2020-10-28 EP claimed
CN-111801099-A Pharmaceutical composition for cancer treatment 因佩蒂斯生物科学有限公司 2020-10-20 CN claimed
US-20200316077-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER IMPETIS BIOSCIENCES LTD. (IN) 2020-10-08 US claimed
US-20150087643-A1 Substituted Fused Pyrimidine Compounds ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) 2015-03-26 US claimed
EP-2405917-B1 SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS ADVINUS THERAPEUTICS PRIVATE LTD (IN) 2014-04-23 EP claimed
US-20120115864-A1 Substituted Fused Pyrimidine Compounds ADVINUS THERAPEUTICS LIMITED (IN) 2012-05-10 US claimed
US-20240307402-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER IMPETIS BIOSCIENCES LTD. (IN) 2024-09-19 US disclosed
CN-118001282-A Pharmaceutical composition for cancer treatment 因佩蒂斯生物科学有限公司 2024-05-10 CN disclosed
EP-3727391-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER Impetis Biosciences Ltd. (IN) 2020-10-28 EP disclosed
CN-111801099-A Pharmaceutical composition for cancer treatment 因佩蒂斯生物科学有限公司 2020-10-20 CN disclosed
US-9284316-B2 Substituted fused pyrimidine compounds ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) 2016-03-15 US disclosed
US-20150087643-A1 Substituted Fused Pyrimidine Compounds ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) 2015-03-26 US disclosed
US-8859566-B2 Substituted fused pyrimidine compounds ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) 2014-10-14 US disclosed
EP-2405917-B1 SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS ADVINUS THERAPEUTICS PRIVATE LTD (IN) 2014-04-23 EP disclosed
US-20120115864-A1 Substituted Fused Pyrimidine Compounds ADVINUS THERAPEUTICS LIMITED (IN) 2012-05-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200316077-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER ADORA2B, ADORA2A, ADORA3 ADORA2B 1/4885ADORA1 8/4885FLT3 1192/4885
US-20120115864-A1 Substituted Fused Pyrimidine Compounds ADORA2A, ADORA1, ADORA3 ADORA2B 4/4885ADORA1 2/4885FLT3 1365/4885
US-20150087643-A1 Substituted Fused Pyrimidine Compounds ADORA2A, ADORA1, ADORA3 ADORA2B 4/4885ADORA1 2/4885FLT3 1382/4885
US-20240307402-A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER ADORA2B, ADORA2A, ADORA3 ADORA2B 1/4885ADORA1 8/4885FLT3 1192/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.