Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 7/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 6/20 | 0.34 |
| ▸ | COQ8A | Q8NI60 | 6/20 | 0.34 |
| ▸ | NLK | Q9UBE8 | 6/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.34 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.34 |
| ▸ | EPHA8 | P29322 | 2/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25465413 | 0.83 | HTR1A (0.55) | HTTEGFRPTK6PDGFRAGAK | |
| SCHEMBL26862940 | 0.80 | HTT (0.49) | HTTEGFRPTK6PTGS1PTGS2 | |
| SCHEMBL26656467 | 0.78 | PTGS1 (0.39) | HTTEGFRPTK6PDGFRAPTGS1 | |
| SCHEMBL26863122 | 0.78 | MAP2K1 (0.43) | EGFRSRCERBB2 | |
| SCHEMBL26656469 | 0.78 | CA1 (0.47) | HTTEGFRPTGS1PTGS2GAK | |
| SCHEMBL26863377 | 0.77 | GAK (0.39) | HTTEGFRPTK6PDGFRAPTGS1 | |
| SCHEMBL25465414 | 0.77 | GAK (0.61) | HTTEGFRPTK6PDGFRAGAK | |
| SCHEMBL26864357 | 0.76 | PDGFRA (0.36) | PDGFRA | |
| SCHEMBL26863114 | 0.74 | PTGS1 (0.41) | HTTPTK6PTGS1PTGS2GAK | |
| SCHEMBL25465062 | 0.73 | EGFR (0.55) | EGFRPDGFRAGAKRIPK2COQ8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023225001-A1 | NAPHTHYRIDINE BASED ENPP1 MODULATORS AND USES THEREOF | Vir Biotechnology, Inc. (US) | 2023-11-23 | — | — | WO | disclosed |