Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.45 |
| ▸ | GAK | O14976 | 2/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.44 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26863114 | 0.84 | PTGS1 (0.41) | HTTGAKERBB2PTK6PTGS1 | |
| SCHEMBL26865131 | 0.81 | HTT (0.43) | HTTALKGAKRIPK2COQ8A | |
| SCHEMBL26862939 | 0.80 | HTT (0.40) | HTTGAKRIPK2COQ8ANLK | |
| SCHEMBL26656469 | 0.80 | CA1 (0.47) | HTTGAKPTGS1PTGS2EGFR | |
| SCHEMBL26870392 | 0.78 | ALDH1A1 (0.39) | HTTGAKPTK6PTGS1PTGS2 | |
| SCHEMBL26656467 | 0.78 | PTGS1 (0.39) | HTTGAKRIPK2PTK6PTGS1 | |
| SCHEMBL26863377 | 0.77 | GAK (0.39) | HTTGAKRIPK2PTK6PTGS1 | |
| SCHEMBL31263996 | 0.76 | AURKA (0.46) | AURKAKDM4EMEN1GLAGAA | |
| SCHEMBL31263786 | 0.75 | HTT (0.63) | HTTMEN1MAPTRECQLKMT2A | |
| SCHEMBL16171228 | 0.72 | TOP2A (0.43) | HTTALKGAKRIPK2COQ8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023225001-A1 | NAPHTHYRIDINE BASED ENPP1 MODULATORS AND USES THEREOF | Vir Biotechnology, Inc. (US) | 2023-11-23 | — | — | WO | disclosed |