Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.37 |
| ▸ | TUBB | P07437 | 2/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.37 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26863377 | 0.87 | GAK (0.39) | PTGS1PTGS2HTTSLC40A1TUBB4A | |
| SCHEMBL26870392 | 0.86 | ALDH1A1 (0.39) | PTGS1PTGS2HTTSLC40A1PTK6 | |
| SCHEMBL26862940 | 0.84 | HTT (0.49) | PTGS1PTGS2HTTPTK6GAK | |
| SCHEMBL26656467 | 0.83 | PTGS1 (0.39) | PTGS1PTGS2HTTTUBB4ATUBB | |
| SCHEMBL26862956 | 0.82 | GAK (0.36) | PTGS1PTGS2HTTTUBB4ATUBB | |
| SCHEMBL26864601 | 0.82 | GAK (0.36) | PTGS1PTGS2HTTTUBB4ATUBB | |
| SCHEMBL26656469 | 0.81 | CA1 (0.47) | PTGS1PTGS2HTTGAK | |
| SCHEMBL26862948 | 0.81 | GAK (0.37) | PTGS1PTGS2HTTPTK6GAK | |
| SCHEMBL26862944 | 0.81 | GAK (0.37) | PTGS1PTGS2HTTPTK6GAK | |
| SCHEMBL26862953 | 0.81 | IKBKB (0.38) | PTGS1PTGS2HTTSLC40A1GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023225001-A1 | NAPHTHYRIDINE BASED ENPP1 MODULATORS AND USES THEREOF | Vir Biotechnology, Inc. (US) | 2023-11-23 | — | — | WO | disclosed |