Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 5/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.35 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.35 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.35 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.35 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.35 |
| ▸ | TXK | P42681 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | IDH2 | P48735 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26862944 | 1.00 | GAK (0.37) | GAKPTGS1PTGS2RIPK2COQ8A | |
| SCHEMBL26863383 | 0.86 | PTGS1 (0.34) | GAKPTGS1PTGS2RIPK2COQ8A | |
| SCHEMBL26863377 | 0.84 | GAK (0.39) | GAKPTGS1PTGS2RIPK2HTT | |
| SCHEMBL26864598 | 0.84 | IKBKB (0.38) | GAKPTGS1PTGS2HTTCDK1 | |
| SCHEMBL26862953 | 0.84 | IKBKB (0.38) | GAKPTGS1PTGS2HTTCDK1 | |
| SCHEMBL26865331 | 0.83 | BRAF (0.36) | GAKPTGS1PTGS2RIPK2HTT | |
| SCHEMBL30666120 | 0.83 | BRAF (0.36) | GAKPTGS1PTGS2RIPK2HTT | |
| SCHEMBL26864188 | 0.83 | BRAF (0.36) | GAKPTGS1PTGS2RIPK2HTT | |
| SCHEMBL26870392 | 0.83 | ALDH1A1 (0.39) | GAKPTGS1PTGS2HTTPTK6 | |
| SCHEMBL26862941 | 0.83 | ALDH1A1 (0.41) | GAKPTGS1PTGS2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023225001-A1 | NAPHTHYRIDINE BASED ENPP1 MODULATORS AND USES THEREOF | Vir Biotechnology, Inc. (US) | 2023-11-23 | — | — | WO | disclosed |