Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27599507 | 0.84 | CYP19A1 (0.44) | ALDH1A1TDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12479193 | 0.79 | CYP11B2 (0.57) | ALDH1A1MAPK1NPC1RAB9ANPSR1 | |
| SCHEMBL10728528 | 0.75 | ALDH1A1 (0.53) | ALDH1A1HSD17B10L3MBTL1MAPK1ALOX12 | |
| SCHEMBL11331899 | 0.74 | — | — | |
| SCHEMBL291980 | 0.74 | ALDH1A1 (0.48) | ALDH1A1NOX1MAPK1LMNAIDO1 | |
| SCHEMBL223592 | 0.73 | ALDH1A1 (0.60) | ALDH1A1TDP1HSD17B10CTSDTSHR | |
| SCHEMBL446252 | 0.73 | ALDH1A1 (0.45) | ALDH1A1NOX1TSHRL3MBTL1MAPK1 | |
| SCHEMBL223591 | 0.73 | ALDH1A1 (0.60) | ALDH1A1TDP1HSD17B10CTSDTSHR | |
| SCHEMBL7492108 | 0.73 | ALDH1A1 (0.60) | ALDH1A1TDP1HSD17B10CTSDTSHR | |
| SCHEMBL5098432 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016123627-A1 | ISOQUINILINE AND NAPTHALENE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOUNDS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | VANDERBILT UNIVERSITY (US) | 2016-08-04 | — | — | WO | claimed |
| EP-0132814-B1 | ESTER DERIVATIVE OF SUBSTITUTED ACETIC ACID AND PREPARING THE SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 1988-12-21 | — | — | EP | claimed |
| US-4603217-A | ANTIINFLAMMATORY AGENTS | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1986-07-29 | — | — | US | claimed |
| EP-0132814-A1 | Ester derivative of substituted acetic acid and preparing the same | Kaken Pharmaceutical Co., Ltd. (JP) | 1985-02-13 | — | — | EP | claimed |
| US-20170158681-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2017-06-08 | — | — | US | disclosed |
| US-8168634-B2 | Thiazole derivatives as kinase inhibitors | UCB PHARMA S.A. (BE) | 2012-05-01 | — | — | US | disclosed |
| CN-102159535-A | Potassium ion channel modulators and uses thereof | UNIV RAMOT | 2011-08-17 | — | — | CN | disclosed |
| US-20100298310-A1 | Thiazole Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-11-25 | — | — | US | disclosed |
| EP-2084155-A1 | THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma S.A. (BE) | 2009-08-05 | — | — | EP | disclosed |
| EP-2035436-A1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma S.A. (BE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008047109-A1 | THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2008-04-24 | — | — | WO | disclosed |
| WO-2008001076-A1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2008-01-03 | — | — | WO | disclosed |
| US-4727060-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1988-02-23 | — | — | US | disclosed |
| US-4719288-A | HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1988-01-12 | — | — | US | disclosed |
| US-4613676-A | PEPTIDES | CIBA-GEIGY CORPORATION (US) | 1986-09-23 | — | — | US | disclosed |
| US-4603217-A | ANTIINFLAMMATORY AGENTS | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1986-07-29 | — | — | US | disclosed |
| EP-0184550-A2 | 5-Amino-4-hydroxy valeryl amide derivatives | CIBA-GEIGY AG (CH) | 1986-06-11 | — | — | EP | disclosed |
| EP-0143746-A2 | 5-Amino 4-hydroxy-valeryl-substituted derivatives | CIBA-GEIGY AG (CH) | 1985-06-05 | — | — | EP | disclosed |
| EP-0132814-A1 | Ester derivative of substituted acetic acid and preparing the same | Kaken Pharmaceutical Co., Ltd. (JP) | 1985-02-13 | — | — | EP | disclosed |
| US-3895063-A | Substituted Anilino Benzyl Alcohols | CIBA GEIGY CORP | 1975-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158681-A1 | HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM5A, KDM1A | ALDH1A1 588/4885NOX1 992/4885TDP1 179/4885 |
| US-20100298310-A1 | Thiazole Derivatives as Kinase Inhibitors | TEC, BTK, PI4KA | ALDH1A1 3055/4885NOX1 1270/4885TDP1 711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.