Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4807116 | 0.96 | HRH3 (0.50) | HRH3HRH4L3MBTL1CYP2D6KCNH2 | |
| SCHEMBL31243628 | 0.91 | CYP2D6 (0.54) | HRH3L3MBTL1CYP2D6KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7396009 | 0.89 | CYP2D6 (0.53) | HRH3L3MBTL1CYP2D6KDM4EALDH1A1 | |
| SCHEMBL29085663 | 0.87 | PAOX (0.49) | HRH3CYP2D6KCNH2KDM4EALDH1A1 | |
| SCHEMBL28927092 | 0.84 | CXCR4 (0.47) | HRH1KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL167666 | 0.84 | L3MBTL1 (0.52) | HRH3L3MBTL1CYP2D6HRH1KDM4E | |
| SCHEMBL5093580 | 0.82 | L3MBTL1 (0.55) | L3MBTL1KDM4EALDH1A1CYP1A2MAPK1 | |
| SCHEMBL22266346 | 0.82 | CXCR4 (0.44) | HRH1KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8568373 | 0.81 | HRH3 (0.52) | HRH3HRH4KCNH2HRH1KDM4E | |
| SCHEMBL23407993 | 0.79 | ALDH1A1 (0.49) | HRH3L3MBTL1CYP2D6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142518-B1 | 3,4-DIHYDROQUINAZOLINE DERIVATIVES | DONGWOO SYNTECH CO LTD (KR) | 2012-05-02 | — | — | EP | disclosed |
| US-8168646-B2 | 3,4-dihydroquinazoline derivatives | DONGWOO SYNTECH CO., LTD. (KR) | 2012-05-01 | — | — | US | disclosed |
| EP-2142518-A1 | 3,4-DIHYDROQUINAZOLINE DERIVATIVES | Dongwoo Syntech Co., Ltd. (KR) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008136631-A1 | 3,4-DIHYDROQUINAZOLINE DERIVATIVES | DONGWOO SYNTECH CO., LTD. (KR) | 2008-11-13 | — | — | WO | disclosed |