SCHEMBL2686572

SCHEMBL2686572

COCC1(C(=O)c2cccc(C)c2)c2ccccc2-c2ccccc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.41
MEN1 O00255 3/20 0.41
MAPT P10636 3/20 0.41
ALDH1A1 P00352 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41
TDP2 O95551 1/20 0.41
PARP1 P09874 1/20 0.41
SMN1; SMN2 Q16637 3/20 0.40
CTNNB1 P35222 1/20 0.40
WNT3A P56704 1/20 0.40
HPGD P15428 3/20 0.39
TDP1 Q9NUW8 1/20 0.39
HTT P42858 2/20 0.39
GAA P10253 2/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HSP90AA1 P07900 1/20 0.39
GFER P55789 1/20 0.39
KCNK3 O14649 2/20 0.39
NPC1 O15118 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2689178 0.86 MAPT (0.42) KMT2AMEN1MAPTALDH1A1SMN1; SMN2
SCHEMBL2685931 0.85 NPC1 (0.39) KMT2AMEN1MAPTALDH1A1NPSR1
SCHEMBL2687542 0.76 NPC1 (0.41) KMT2AMEN1MAPTALDH1A1HPGD
SCHEMBL16036326 0.76 PDK2 (0.47) KMT2AMEN1MAPTALDH1A1HPGD
SCHEMBL16035187 0.76 PDK2 (0.43) MAPTALDH1A1NPSR1HPGDHTT
SCHEMBL2687407 0.75 MAPT (0.41) KMT2AMEN1MAPTALDH1A1NPSR1
SCHEMBL16034381 0.75 THRB (0.48) KMT2AMEN1MAPTALDH1A1NPSR1
SCHEMBL16034976 0.73 ALDH1A1 (0.44) KMT2AMEN1MAPTALDH1A1NPSR1
SCHEMBL16034336 0.73 ALDH1A1 (0.41) KMT2AMEN1MAPTALDH1A1TDP2
SCHEMBL2686286 0.72 MAPT (0.40) KMT2AMEN1MAPTALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3118226-A1 HIGH ACTIVITY CATALYST FOR OLEFIN POLYMERIZATION BASF Corporation (US) 2017-01-18 EP claimed
EP-2782938-B1 HIGH ACTIVITY CATALYST FOR OLEFIN POLYMERIZATION BASF CORP (US) 2016-08-31 EP claimed
EP-2782938-A1 HIGH ACTIVITY CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND METHOD OF USING THE SAME BASF Corporation (US) 2014-10-01 EP claimed
CN-104053682-A High activity catalyst component for olefin polymerization and method of using the same BASF SE 2014-09-17 CN claimed
WO-2013077837-A1 HIGH ACTIVITY CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND METHOD OF USING THE SAME BASF CORPORATION (US) 2013-05-30 WO claimed
US-8227370-B2 High activity catalyst component for olefin polymerization and method of using the same BASF CORPORATION (US) 2012-07-24 US claimed
US-20120116031-A1 High Activity Catalyst Component for Olefin Polymerization and Method of Using the Same BASF CORPORATION (US) 2012-05-10 US claimed
EP-3118226-A1 HIGH ACTIVITY CATALYST FOR OLEFIN POLYMERIZATION BASF Corporation (US) 2017-01-18 EP disclosed
EP-2782938-B1 HIGH ACTIVITY CATALYST FOR OLEFIN POLYMERIZATION BASF CORP (US) 2016-08-31 EP disclosed
US-8227370-B2 High activity catalyst component for olefin polymerization and method of using the same BASF CORPORATION (US) 2012-07-24 US disclosed
US-20120116031-A1 High Activity Catalyst Component for Olefin Polymerization and Method of Using the Same BASF CORPORATION (US) 2012-05-10 US disclosed