Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.52 |
| ▸ | CDK2 | P24941 | 7/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26870935 | 0.84 | CDK2 (0.39) | CHEK1CCNA2CDK2CCNA1CSNK2A1 | |
| SCHEMBL26868591 | 0.84 | CCNA2 (0.52) | CHEK1CCNA2CDK2CCNA1CSNK2A1 | |
| SCHEMBL26868862 | 0.84 | CDK2 (0.52) | CHEK1CCNA2CDK2CCNA1CSNK2A1 | |
| SCHEMBL26869077 | 0.82 | CDK9 (0.38) | CHEK1CCNA2CDK2CCNA1CSNK2A1 | |
| SCHEMBL26869091 | 0.80 | KDM4E (0.35) | CHEK1CCNA2CDK2CCNA1CSNK2A1 | |
| SCHEMBL26867729 | 0.80 | CDK2 (0.44) | CHEK1CCNA2CDK2CCNA1CCNT1 | |
| SCHEMBL26871753 | 0.79 | CSNK2B (0.44) | CHEK1CCNA2CDK2CCNA1CSNK2A1 | |
| SCHEMBL26867963 | 0.79 | CHEK1 (0.32) | CHEK1CCNA2CDK2CCNA1KDM4E | |
| SCHEMBL26868391 | 0.78 | CHEK1 (0.35) | CHEK1CCNA2CDK2CCNA1PLAT | |
| SCHEMBL26867958 | 0.78 | TYK2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4282868-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVE, AND COMPOSITIONS AND MEDICAL USE THEREOF | Shanghai Haiyan Pharmaceutical Technology Co., Ltd (CN) | 2023-11-29 | — | — | EP | disclosed |