Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD2 | Q15562 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL26686919 | 0.99 | TEAD2 (0.39) | TEAD2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL30685706 | 0.92 | ALDH1A1 (0.41) | TEAD2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL26686907 | 0.78 | ALDH1A1 (0.38) | ALDH1A1NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL26686903 | 0.78 | KDM4E (0.42) | KDM4EHPGDKMT2AGAAADORA3 | |
| Hydrochloric Acid SCHEMBL26686999 | 0.77 | ALDH1A1 (0.37) | ALDH1A1NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL24687912 | 0.75 | ALDH1A1 (0.41) | ALDH1A1NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL30685698 | 0.74 | KDM4E (0.39) | ALDH1A1NPC1RAB9AKDM4EHPGD | |
| SCHEMBL30685681 | 0.72 | ALDH1A1 (0.39) | ALDH1A1NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL14139187 | 0.71 | MAPK1 (0.45) | ALDH1A1NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL31667548 | 0.70 | POLB (0.50) | ALDH1A1NPC1RAB9AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250243222-A1 | PYRIMIDINE BASED MODULATORS AND USES THEREOF | QUANTA THERAPEUTICS, INC. | 2025-07-31 | — | — | US | disclosed |
| WO-2025106901-A1 | COMBINATION CANCER THERAPIES WITH A KRAS MODULATOR AND AN RTK-MAPK PATHWAY INHIBITOR | QUANTA THERAPEUTICS, INC. (US) | 2025-05-22 | — | — | WO | disclosed |
| WO-2025106905-A1 | COMBINATION THERAPIES WITH A KRAS MODULATOR AND AN IMMUNOMODULATOR INHIBITOR | QUANTA THERAPEUTICS, INC. (US) | 2025-05-22 | — | — | WO | disclosed |
| EP-4532494-A1 | PYRIMIDINE BASED MODULATORS AND USES THEREOF | Quanta Therapeutics, Inc. (US) | 2025-04-09 | — | — | EP | disclosed |
| CN-119604501-A | Pyrimidine-based modulators and uses thereof | 光达治疗公司 | 2025-03-11 | — | — | CN | disclosed |
| US-12145947-B2 | Pyrimidine based modulators and uses thereof | QUANTA THERAPEUTICS, INC. (US) | 2024-11-19 | — | — | US | disclosed |
| US-20240199650-A1 | PYRIMIDINE BASED MODULATORS AND USES THEREOF | QUANTA THERAPEUTICS, INC. | 2024-06-20 | — | — | US | disclosed |
| WO-2023230190-A1 | PYRIMIDINE BASED MODULATORS AND USES THEREOF | QUANTA THERAPEUTICS, INC. (US) | 2023-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12145947-B2 | Pyrimidine based modulators and uses thereof | KRAS, NRAS, DPYD | TEAD2 1189/4885ALDH1A1 1020/4885NPC1 2159/4885 |
| US-20250243222-A1 | PYRIMIDINE BASED MODULATORS AND USES THEREOF | KRAS, NRAS, DPYD | TEAD2 1189/4885ALDH1A1 1020/4885NPC1 2159/4885 |
| US-20240199650-A1 | PYRIMIDINE BASED MODULATORS AND USES THEREOF | KRAS, NRAS, DPYD | TEAD2 1189/4885ALDH1A1 1020/4885NPC1 2159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.